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CME Metabolic Comorbidities in Patients With Bipolar Disorder
April 2011
Medical comorbidities, particularly cardiometabolic diseases, are highly prevalent among patients with bipolar disorder. A bidirectional relationship exists between psychiatric disorders and medical conditions, which can negatively impact the course of disease and has important implications for management.
This activity will help clinicians recognize the clinical overlap and interactions between metabolic comorbidities and psychiatric illness, and develop effective treatment strategies that reduce the burden of medical conditions in patients with bipolar disorder.
This e-newsletter was submitted by SciMed, LLC and supported by an educational grant from Bristol-Myers Squibb and Otsuka America Pharmaceuticals Inc. It was peer reviewed by Current Psychiatry.
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Transcranial Magnetic Stimulation for Major Depressive Disorder: A Pragmatic Approach to Implementing TMS in a Clinical Practice
December 2010
 More than 4 million patients need a new option because they do not receive adequate benefit from antidepressant medication for their major depressive illness. NeuroStar Transcranial Magnetic Stimulation Therapy is a nonsystemic depression option available for outpatient treatment in a psychiatrist’s office. Transcranial magnetic stimulation (TMS) uses a pulsed magnet field to modulate brain cortical activity in the region of the brain associated with mood. NeuroStar TMS has been shown in clinical trials to be an effective antidepressant without the systemic side effects associated with antidepressant medication. NeuroStar TMS is the only TMS device cleared by the FDA for the treatment of adult patients with major depressive disorder (MDD) who have not benefited from prior antidepressant medication. For this supplement a panel of psychiatrists who are experts in the field of TMS was convened, and they discuss the role for TMS in the treatment of MDD and their experiences with the use of TMS in their clinical practices.
This supplement was submitted and supported by an educational grant from Neuronetics, Inc. It was peer reviewed by Current Psychiatry.
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CME Bipolar Disorder: Differential Diagnosis and Evidence-Based Treatment Strategies
November 2010
 Bipolar disorder (BD) ranks high among the most prevalent and frequently underdiagnosed and undertreated affective disorders in the United States. Despite the growth in research in recent years, an estimated 69% of people with BD have been misdiagnosed; most notably, patients with BD receive a mean of 3.5 other diagnoses and consult 4 physicians before being accurately diagnosed. BD increases the risk for suicide and is associated with several psychiatric and medical comorbidities, including substance misuse, anxiety disorders, cardiovascular disease, metabolic syndrome, and hyperten¬sion. An increasing body of evidence suggests that when appropriate pharmacotherapeutic interventions are initiated early in the course of the disorder, the ultimate prognosis is substantially improved. Longitudinal data on the management of patients with BD, including monitoring for efficacy, safety, adherence, and comorbidities, are available to provide practical, clinically applicable information.
This multimedia resource compendium is designed to educate healthcare professionals about recent developments in the differential diagnosis and medical management of BD, with a focus on a patient-centered, individualized approach to treatment. Psychiatrists and neurologists, as well as pharma¬cists, primary care physicians, and other multidisciplinary team members, may find this compendium of particular value as a clinical reference tool to help improve care and outcomes of their patients with BD.
This supplement was submitted by Albert Einstein College of Medicine, Montefiore Medical Center, the College of Psychiatric and Neurologic Pharmacists (CPNP), and Asante Communications, LLC, and supported by educational grants from Eli Lilly and Company and Janssen, Division of Ortho-McNeil Janssen Pharmaceuticals, Inc., administered by Ortho-McNeil Janssen Scientific Affairs.
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CME Long-Term Treatment of Schizophrenia: Minimizing Side Effect Burden to Improve Patient Outcomes
November 2010
Management of schizophrenia by psychiatrists commonly is limited to interventions mitigating the positive and, to a lesser extent, negative symptoms that are the most immediate and often considered the most debilitating. However, side effects associated with antipsychotics used to treat these symptoms can have a negative impact on overall patient outcome.
This activity will help clinicians understand the importance of evaluating different antipsychotic side effect profiles when treating patients with schizophrenia, assess the impact of side effects on a patient’s recovery from schizophrenia, and predict potential side effect risks associated with different antipsychotic medications based on their neuroreceptor binding properties.
This e-newsletter was submitted by SciMed and supported by an educational grant from Merck. It was peer reviewed by Current Psychiatry. This CME activity is part of a curriculum that discusses effective management of patients with schizophrenia and includes virtual patient visits with Jason. These interactive activities highlight the importance of patient-directed goals in managing patients attempting to achieve functional recovery from schizophrenia. For more information and to view the Virtual Patient Visits, visit the Virtual Clinic.
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CME Effective Strategies for Patients With Complex Depression in Psychiatric Practice
November 2010
 MDD is a serious chronic illness that affects the lives of millions of patients and their families, and poses challenges for psychiatrists caring for these individuals. Despite the availability of effective treatments, many patients with MDD fail to achieve remission, the primary goal of therapy. More than half of patients either do not respond or only partially respond to first-line antidepressants. In addition, comorbid chronic medical conditions complicate the clinical presentation and treatment decisions, and require special consideration. A number of effective pharmacologic treatment strategies have been studied for patients in these challenging situations, including switching to another approved antidepressant, combining treatment with an approved antidepressant agent, and augmenting with an agent of a different class.
This supplement was submitted by SciMed and supported by an educational grant from AstraZeneca. It was peer reviewed by Current Psychiatry and Annals of Clinical Psychiatry.
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Virtual Clinic Powered by  with content provided by its educational partners
Featured Case
Lisa Visit 1: A woman with bipolar disorder who wants a second opinion
"I'm not happy with my current treatment"
Meet and Treat Lisa in the Virtual Clinic, designed to replicate the real-world experiences of busy clinicians in a private practice setting. These activities will focus on the challenges in ongoing maintenance therapy of patients with bipolar disorder and will present evidence-based intervention strategies to both focus on patient-identified concerns and overcoming obstacles to long-term wellness.
For more cases, click here
Lisa Visit 2: A woman with bipolar disorder who has switched mood stabilizers in order to lose weight
"I'm beginning to feel worse."
For more cases, click here
CME Expanding the Treatment Paradigm in Patients With Schizophrenia: Beyond Psychotic Symptoms
October 2010
Management of schizophrenia by psychiatrists is commonly limited to interventions mitigating the positive symptoms that are the most immediate and often considered the most debilitating. A broader understanding of the impact of negative symptoms and cognitive impairment is needed to improve patients’ overall health and ability to function.
This activity will help clinicians understand the importance of cognitive and negative symptoms in functional impairment, describe mechanisms of action for various pharmacologic medications and how they impact efficacy, and address the importance of improving patient outcomes by developing treatment strategies designed to address nonpsychotic symptom domains of schizophrenia.
This e-newsletter was submitted by SciMed and supported by an educational grant from Merck. It was peer reviewed by Current Psychiatry.
This CME activity is part of a curriculum that discusses effective management of patients with schizophrenia and includes virtual patient visits with Jason. These interactive activities highlight the importance of patient-directed goals in managing patients attempting to achieve functional recovery from schizophrenia. For more information and to view the Virtual Patient Visits, visit the Virtual Clinic.
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CME Differential Diagnosis and Therapeutic Management of Schizoaffective Disorder
October 2010
 Patients with schizoaffective disorder (SAD) meet criteria for schizophrenia, while also meeting criteria for major depressive disorder or mania, and will have periods of psychosis without mood disorder symptoms. SAD remains underdiagnosed, in part because it is frequently confused with other psychiatric disorders with overlapping diagnostic criteria—chiefly schizophrenia, bipolar disorder, and major depressive disorder. Understanding collaborative management of patients with SAD is an important educational imperative for psychiatrists and other health care professionals. Considerable gaps in level-1 evidence mirror the need for psychiatrists to exchange insights into this heterogeneous clinical construct and its clinical management.
This activity is jointly sponsored by Albert Einstein College of Medicine, Montefiore Medical Center, and Asante Communications, LLC, and is supported by an educational grant from Janssen, Division of Ortho-McNeil-Janssen Pharmaceuticals, Inc, administered by Ortho-McNeil-Janssen Scientific Affairs, LLC.
CME Proceedings and Data From the Bipolar Summit
March 2010 CE/CME expired
 Bipolar disorder (BD) is a chronic psychological illness of substantial morbidity and mortality characterized by frequent episodes of mania and depression. This disorder is of particular importance to health care professionals given that it affects up to 3% of the general population and causes a significant impact on the patient's quality of life, as well as a considerable economic burden on both the individual and society.
In November 2009, an expert panel of 7 nationally recognized psychiatric experts convened at the Bipolar Summit. Summit members presented clinical data about six statements that broadly addressed recent advances in the understanding of Bipolar Disorder. The experts voted on the validity of each statement in light of the strength of the available evidence; the results of the experts’ ratings were then compared with clinical psychiatrists in the community using a national survey, and recommendations were made for future research. This activity will provide an evidence-based evaluation surrounding the treatment of patients with BD using pharmacologic and psychosocial therapies. The six areas of clinical focus that are explored in this supplement include brain alterations in bipolar patients, bipolar NOS (not otherwise specified) diagnosis and treatment, residual bipolar-related symptoms, use of antidepressants in the treatment of bipolar disorder, treating substance-abuse disorders in bipolar patients, and use of second-generation antipsychotics as mood stabilizers. This activity is hosted by the University of Minnesota and Consensus Medical Communications. This activity was funded through an educational grant from Janssen, L.P. This grant is administered by Ortho-McNeil Janssen Scientific Affairs, LLC.
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CME Maintaining wellness in patients with bipolar disorder: moving beyond efficacy to effectiveness
October 2009 CE/CME expired
 Bipolar disorder (BD) is challenging to diagnose because it is often comorbid with other psychiatric illnesses, drug and alcohol abuse, and physical illness. Since BD is a chronic disorder, long-term treatment with both pharmacologic and psychosocial therapies is needed.
This activity will help clinicians develop an evidence-based approach to therapy, integrate nonpharmacologic management strategies into treatment programs, and create long-term treatment strategies designed to optimize patient outcomes while minimizing medication-related adverse events.
This supplement was submitted by SciMed and supported by an educational grant from AstraZeneca. It was peer reviewed by Current Psychiatry and Annals of Clinical Psychiatry.
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Diagnosing and managing psychotic and mood disorders
December 2008 CE/CME expired
 The diagnosis and management of psychotic and mood disorders is an evolving process and an important topic for continuing medical education. To facilitate a dialogue on the identification and treatment of psychotic and mood disorders, we have invited 4 expert faculty members to present actual patient cases. The learning objectives of this CME program are: (1) to achieve early and accurate diagnosis of patients with psychotic and mood disorders, using effective screening tools as needed; (2) to determine the most appropriate monotherapy or combination therapy for short- and long-term treatment; and (3) to review the mechanisms of action and metabolism of medications used for these conditions.This CME activity was developed through the sponsorship of the University of Cincinnati and supported by an educational grant from AstraZeneca.
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Complete program material, including podcasts and newsletters
Stay awake! Understanding, diagnosing, and successfully managing narcolepsy
December 2007 CE/CME expired
 Narcolepsy is a chronic, neurologic sleep disorder resulting from the dysregulation of sleep-wake cycles. Although the exact etiology of narcolepsy is still unknown, clinical understanding of the underlying causes as well as the treatment options have increased in the last decade. This supplement will review the epidemiology, diagnosis, pathophysiology, pharmacology, and treatment strategies for narcolepsy, and is intended to provide a current, evidence-based examination of narcolepsy. This CME activity is sponsored by The Chatham Institute and supported by an educational grant from Jazz Pharmaceuticals.
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Challenges in recognition, clinical management, and treatment of bipolar disorder at the interface of psychiatric medicine and primary care
November 2007
 Bipolar disorder is often mistaken by primary care providers as a major depressive episode, and is also under-recognized in psychiatric settings. Based on the insights of a panel of primary care and psychiatric experts, this supplement provides extensive practical, case-based insights into the diagnosis, management, and collaborative care of patients with bipolar disorder in a variety of settings.
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