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Pros and cons of pill splitting

May reduce cost and fine-tune therapy, but is it safe?

Vol. 5, No. 12 / December 2006

Clinicians and patients look to pill splitting to reduce psychotropics’ costs and fine-tune pharmacotherapy, but pill splitting has not been rigorously studied for safety or efficacy. It is important to understand the risks and benefits of pill splitting before you recommend the practice to patients.

Pros of pill splitting

Lower costs for patients. Many psychotropics come in multiple strengths, and one larger pill often costs less than 2 smaller pills of equivalent dosage.1 Writing a prescription for a higher dose and instructing the patient to cut the pill in half can lower costs.

Fine-tune titration. Pill splitting allows you to prescribe a lower strength to gradually titrate dosages up or taper them down. This practice can prevent side effects and improve adherence because a lower dose may have a more favorable pharmacokinetic profile.

Improve tolerability. Patients might better tolerate half a pill taken twice daily rather than an entire pill once daily. A smaller dose may prevent a spike in serum level, which could aid tolerability.

Questions to ask before you recommend pill splitting

  1. Will there be a cost saving for the patient?
  2. Can the patient understand and follow your recommendations?
  3. Can the patient tolerate minor dosage variability that can occur with pill splitting?
  4. Is the medication’s integrity maintained when the pill is split?

If the answer is yes to all 4 questions, then pill splitting is an option.

Cons of pill splitting

Unequal dosing. In most instances, pill splitting leads to slightly unequal dosing.2 This could be a problem if:

  • the medication such as lithium has a narrow therapeutic index
  • the patient’s condition is unstable
  • the patient’s condition is stable but minor dose variations might cause problems, such as a patient who relapses with small dosing changes.

Slow-release tablets. Pill splitting is contraindicated if the pill is enterically coated or has a slow-release mechanism that will be compromised if the pill is broken (Table).


Appropriate and inappropriate medications for pill splitting

OK to split

Do not split

Adderall tablets

Adderall XR capsules*

Effexor tablets

Effexor-XR capsule*

Paxil or paroxetine tablets

Paxil CR

Prozac 10 mg tablet or fluoxetine tablets

Prozac 20 mg capsule

Risperdal tablet

Risperdal M-TAB


Tegretol XR

Wellbutrin and bupropion tablets

Wellbutrin XL

Zyprexa tablets

Zyprexa Zydis

Abilify tablets

Concerta capsules

Celexa or citalopram tablets

Cymbalta capsules

Lamictal tablets

Depakote ER

Lexapro tablets


Luvox tablets

Eskalith CR, Lithobid tablets

Remeron or mirtazapine tablets

Geodon capsules

Seroquel tablets

Ritalin LA*

Zoloft tablets

Strattera capsules

* Capsule can be opened and contents sprinkled on food

Tablets may have uneven shapes, making even cuts difficult

Dosage confusion. With cognitively impaired patients, pill splitting could lead to confusion and possible incorrect dosing.

Scoring. Cutting unscored tablets can be difficult, especially if the pills are not round or oval. Because patients can get injured using a knife, recommend pill cutters, which are available at most pharmacies.

Capsule splitting. Some psychotropics are sold only in capsules. Some capsules can be opened and sprinkled on food, but splitting the contents into approximately equal dosages can be difficult.


1. Cohen CI, Cohen SI. Potential cost savings from pill splitting of newer psychotropic medications. Psychiatr Serv 2000;51(4):527-9.

2. Teng J, Song CK, Williams RL, Polli J. Lack of medication dose uniformity in commonly split tablets. J Am Pharm Assoc 2002;42:195-9.

Dr. Rakesh Jain is director of psychopharmacology research, R/D Clinical Research, Inc., Lake Jackson, Texas.

Dr. Shailesh Jain is assistant professor, University of Texas Medical School at San Antonio.

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