Managing first-episode psychosis: Rationale and evidence for nonstandard first-line treatments for schizophrenia
Consider long-acting injectable antipsychotics; use clozapine as second- or third-line therapy only. Second of 2 parts. More
Reducing medical comorbidity and mortality in severe mental illness
Collaboration with primary and preventive care could improve outcomes More
What stalking victims need to restore their mental and somatic health
Victims’ mood, anxiety, and posttraumatic stress symptoms require prompt care More
Fatigue after depression responds to therapy. What are the next steps?
A sufficient base of evidence is often lacking to guide pharmacotherapy for fatigue More
Managing first-episode psychosis: An early stage of schizophrenia with distinct treatment needs
Minimize duration of untreated psychosis; aim for remission More
Official journal of the American Academy of Clinical Psychiatrists—an international forum
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Evidence-Based Reviews

Kristen N. Gardner, PharmD, and Henry A. Nasrallah, MD
Consider long-acting injectable antipsychotics; use clozapine as second- or third-line therapy only. Second of 2 parts.... More »

Evidence-Based Reviews

Swati Rao, MD, Lori Raney, MD, and Glen L. Xiong, MD
Collaboration with primary and preventive care could improve outcomes... More »

Evidence-Based Reviews

Stephen Noffsinger, MD
Victims’ mood, anxiety, and posttraumatic stress symptoms require prompt care... More »
Glen L. Xiong, MD
Glen L. Xiong, MD, explains how preventive medical care can help reduce mortality rates.... More »
Brian O’ Donoghue, MD
Brian O’ Donoghue, MD, emphasizes the importance of early diagnosis and treatment of first-episode psychosis. Also, he discusses on how to create, develop, and run community health clinics for people age 15 to 24 who are experiencing psychosis. Li... More »

Savvy Psychopharmacology

Kristen Wiese, PharmD, and Vicki L. Ellingrod, PharmD, FCCP
Mr. T,  age 23, was given a diagnosis of bipolar disorder 1 year ago. After he experienced inadequate symp­tom relief with valproate, you switched him to extended-release lithium, 1,200 mg/d. Mr. T reported improved mood and stability with this... More »

Cases that Test Your Skills

Adriana Sofia Perilla, MD, Rekha Bandla, DO, and Murali Rao, MD
Mr. M, age 73, feels light-headed and has difficulty following conversations. He has a history of depression, cardiovascular disease, and visual problems. What could be causing his symptoms?... More »

From the Editor

Henry A. Nasrallah, MD
The nearly 1,000-page DSM-5 lists hundreds of psychiatric disorders, with an operational clinical process to distinguish them. Psychiatrists and other mental health practitioners dutifully apply DSM criteria to categorize patients as having a psychot... More »

Malpractice Rx

Annette Reynolds, MD, and Douglas Mossman, MD
Dear Dr. Mossman, Some of my patients e-mail me questions about their prescriptions, test results, treat­ment, appointments, etc. I’m often unsure about the best way to respond. If I use e-mail to communicate with patients, what step(s) should I... More »


Nathaniel DeYoung, PhD, and Brian Shenal, PhD
Brief cognitive screening is essential for assessing neurocognitive disor­ders. Such screening can give clini­cians a snapshot of patients’ cognitive abilities across a range of disorders and help tailor interventions to yield better outcomes. Ap... More »


Richard C. Christensen, MD, MA
Psychiatric providers often encounter older adult patients who report dif­ficulty with memory and express the fear they are “developing dementia.” Often, after a thorough evaluation of the reported deficits and history, we find that a serious or... More »


Radhika Bawa, MD, and Steven Lippmann, MD
Anorexia nervosa can affect a number of systems of the body, including the otolaryngologic presentation of autophonia1,2—a rare hyperperception of an abnormally intense hearing of one’s own voice and respiratory sounds.2 The most common cause of ... More »


Bipolar disorder is characterized by the cyclical occurrence of elevated (manic or hypomanic) and depressed mood states. The illness, which includes the bipolar I and bipolar II subtypes, exacts a heavy toll in terms of quality of life... More »